Methyl gallate

CAS No. 99-24-1

Methyl gallate( Gallincin | NSC 363001 )

Catalog No. M19302 CAS No. 99-24-1

Methyl gallate is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Methyl gallate
  • Note
    Research use only, not for human use.
  • Brief Description
    Methyl gallate is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
  • Description
    Methyl gallate is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
  • In Vitro
    The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
  • In Vivo
    ——
  • Synonyms
    Gallincin | NSC 363001
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Reverse Transcriptase
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    99-24-1
  • Formula Weight
    184.14
  • Molecular Formula
    C8H8O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 160 mg/mL; 868.86 mM
  • SMILES
    COC(=O)c1cc(c(c(c1)O)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang CR,et al. Environ Toxicol Pharmacol. 2014 Mar;37(2):626-37.
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